HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected HamstersArticle Published on 2022-12-292023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] bioenergetics COVID-19 disease hamster hypoxia proteomics. [DOI] 10.3390/ijms24010558 PMC 바로가기
Sotrovimab use in Japanese inpatients with COVID-19: post-infusion adverse eventsReview Published on 2022-12-032023-07-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), [키워드] Fever hypoxia Infusion reaction SARS-CoV-2 Sotrovimab. [DOI] 10.1186/s12879-022-07889-z PMC 바로가기 [Article Type] Review
COVID-19 treatments approved in the European Union and clinical recommendations for the management of non-hospitalized and hospitalized patientsArticle Published on 2022-12-012022-11-15 Journal: Annals of Medicine [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] addition affecting alleviate antiviral medication antiviral medicine approved Baricitinib Care caused Clinical practice clinical recommendations Community courses COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 treatment COVID-19 treatments Critical deaths develop disease disorder drug Dyspnea effective effective drugs European European Medicines Agency European Union Evidence guidelines. Health healthcare hospital Hospitalization Hospitalized hospitalized patient hypoxia Intervention involved life-threatening lung involvement management Mild moderate molnupiravir monoclonal antibodies monoclonal antibody Most patient Multiorgan dysfunction New outcome public health recommendation Remdesivir Respiratory failure rheumatoid arthritis SARS-CoV-2 Septic shock severe symptom Symptom the disease the patient therapy Thromboembolism Tocilizumab treat Treatment treatment strategy union vaccination [DOI] 10.1080/07853890.2022.2133162 PMC 바로가기
Association of SARS-CoV-2 placental histopathology findings with maternal-fetal comorbidities and severity of COVID-19 hypoxiaObservational Study Published on 2022-12-012023-07-06 Journal: The journal of maternal-fetal & neonatal medicine [Category] COVID19(2023년), [키워드] COVID-19 Histopathology hypoxia placenta. SARS-CoV-2 [DOI] 10.1080/14767058.2021.1977791 PMC 바로가기 [Article Type] Observational Study
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Morphological changes without histological myocarditis in hearts of COVID-19 deceased patientsArticle Published on 2022-12-012023-07-09 Journal: Scandinavian cardiovascular journal : SCJ [Category] COVID19(2023년), [키워드] COVID-19 heart hypoxia Inflammation. myocarditis [DOI] 10.1080/14017431.2022.2085320 PMC 바로가기
Real-world effectiveness of steroids in severe COVID-19: a retrospective cohort studyArticle Published on 2022-10-052022-11-16 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] age analysed association clinical co-morbidity Cohort confounder Controlled trial Coronavirus disease 2019 COVID-19 defined Dexamethasone disease Effectiveness EPR Gender hazard hospital Hydrocortisone hypoxia in-hospital mortality individual Methylprednisolone Mortality multivariable multivariate model outcome Patient positive patient Prednisolone protective effect randomised clinical trial reduce replicate replicated reported retrospective cohort study Retrospective study risk SARS-CoV-2 RNA SARS-CoV-2 variant severe COVID-19 shown steroid steroid treatment steroids. treated Treatment viral genome was measured [DOI] 10.1186/s12879-022-07750-3 PMC 바로가기
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome Transcriptome. transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Propofol infusion syndrome & COVID-19 in a victim of multiple gunshot wounds: Diagnostic and therapeutic dilemmasCase report Published on 2022-10-012022-10-05 Journal: Trauma Case Reports [Category] 진단, [키워드] affected Anomaly center Clinical finding condition Contusion COVID COVID-19 Diagnosis differential diagnoses global pandemic gunshot wound Hemorrhagic hypoxia imaging infusion intubation Laboratory lung male more difficult Non-traumatic shock in trauma patients pandemic pathology Patient PCR pharyngeal Pneumonia positive propofol Propofol infusion syndrome retained returned Right upper lobe SARS-CoV-2 Sedation Shock suggested Symptom symptomatic syndrome therapeutic transferred trauma patients worsening [DOI] 10.1016/j.tcr.2022.100687 [Article Type] Case report
COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment managementReview article Published on 2022-10-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome addition aggravate Asymptomatic caused Characteristics chronic liver disease cirrhosis clinical clinical manifestation Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patient Critical death disease dysfunction Epidemic extrapulmonary organs Factors hepatic function Hepatocellular carcinoma hypoxia immune increased risk infection with SARS-CoV-2 inflammatory factor storms Injury liver Liver damage Liver disease liver enzyme Liver function Liver injury liver transplant Liver transplantation management mechanism nonalcoholic fatty liver pathophysiological mechanism Patient patients prevalent public health reperfusion Respiratory disease risk SARS-CoV-2 severe disease Stress Treatment Vaccine [DOI] 10.1016/j.biopha.2022.113568 [Article Type] Review article